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- Laika was a Soviet space dog who became one of the first animals in space, and the first animal to orbit the Earth.
- Able (a rhesus monkey) and Miss Baker (a squirrel monkey) went into space on 28 May 1959. They aboard the JUPITER AM-18 and became the first living beings to successfully return to Earth after travelling in space.
- Otvazhnaya made a flight on 2 July 1959 along with a rabbit named Marfusha and another dog named Snezhinka. She went on to make 5 other flights between 1959 and 1960.
- Sam was a rhesus monkey. It flew to an altitude of 88 km in 1959. It flew on the Little Joe 2 (a test of the Mercury space capsule) in the Mercury Program (Project Mercury was the first human spaceflight program of the United States).
- Belka and Strelka spent a day in space aboard Korabl-Sputnik-2(Sputnik 5) on 19 August 1960 before safely returning to Earth.
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